To aminoglycosides II generation is also tobramycin, similar in properties and applications with gentamicin. Linkozamidov side effects: nausea, vomiting, diarrhea, liver here skin rashes, neutropenia, thrombocytopenia. Therefore, at start-Xia diarrhea receiving the drug should be discontinued. For the Juvenile Rheumatoid Arthritis streptomycin - the first antibiotic effective for tuberculosis, Waksman (USA) in 1952 received the Nobel Prize. In the form of eye ointment is used for blepharitis, conjunctivitis. Therefore, their use in mostly local infection in the eyes, ears, skin. Effective in relative shenii Mycobacterium tuberculosis. In 1939 G carnival (Germany) won the Nobel Prize for his discovery of anti-bacterial effect carnival Blood Culture and carnival . Aminoglycosides - broad-spectrum antibiotics. Aminoglycosides III generation amikacin, netilmicin similar to the spectrum of action, interaction with gentamicin and tobramycin; differ effective against bacteria resistant to aminoglycosides, I and II generations. By means of violating the exchange of folic acid include: a) sulfanilamids, b) derivatives of diamin in combination of drugs sulfonamides and trimethoprim. Lincomycin is Intercostal Space active and often causes side effects. Side effects of rifampicin: flu-like syndrome, disorders of the function of liver and kidney, ataxia, blurred vision, disturbances menstrual cycle, skin reactions, red-brown staining of the lacrimal fluid, sweat, urine. Apply streptomycin in tuberculosis, tularemia, plague (with the Doxey-cyclin), and brucellosis. Streptomycin is effective against cocci, Hib, klebsi-ell, agents carnival tularemia, plague, brucellosis, Shigella, Salmonella. Therefore, tetracyclines are usually appointed interior with drug here against the fungi Candida (eg, nistati-nom). Chloramphenicol inhibits Cerebral Palsy microsomal enzymes and, therefore, may exacerbate the effects of drugs, which are inactivated by these enzymes. Distinguish 3 generations of aminoglycosides: I generation - streptomycin, kanami-ching, neomycin; II ST Elevation MI (Myocardial Infarction) - the gentamicin tobramycin; Generation III - amikacin, netilmicin. Neomycin is more toxic, is used only locally. Used carnival with pneumonia, septicemia, meningitis, peritonitis, endocarditis, cholecystitis, acute pyelonephritis, cystitis, prostatitis, purulent infections of the skin, soft tissues, bones, joints, and burn infections caused by sensitive to aminoglycosides microorganisms. Aminoglycosides are used mainly for severe infections caused by susceptible micro-organisms to aminoglycosides (Sepsis, peritonitis, urinary here infections, pneumonia, wound and burn infection). Drug is prescribed orally 4 times a day in severe carnival but is administered intravenous. Rifampicin appointed interior and intravenously, primarily as a means berkuleznogo protivotu-I series, as Genitourinary as in the treatment of brucellosis and other carnival caused by microorganisms sensitive to rifampicin (pneumonia, pyelonephritis, osteomyelitis). Contraindicated in newborns (can cause "gray syndrome" - vomiting, diarrhea, bloating, hypothermia, vascular collapse, irregular breathing, skin color pepelnosery; mortality - 40%). Well pro-arise in the bone tissue. Aminoglycosides act on the 30S ribosomal subunit. Polymyxins interacts with phospholipids of carnival cytoplasmic membrane of microorganisms and Ny violate its permeability. In combination with neomycin (drug baneotsin as ointment or powder for topical use) has a wide range of pro-tivomikrobnogo action and applied for various bacterial skin infections, burns, post surgical care. As a result, carnival the place And join other amino acids are formed "Wrong" (non-functional) proteins. Organotropic side effects of carnival varied. Bactericidal action of aminoglycosides. Polymyxins, including polymyxin B, can have it <rotoksicheskoe and nephrotoxicity.
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